General and Tissue-Specific tet-Effector Mouse Lines

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Promoter / Transcription unit	Effector	Technique (tg=transgenic, ki=knock-in)	Tissue Specificity	Reference(s)	Contact
CMV	tTA rtTA	tg	diverse tissues	Kistner et al., 1996	h.bujard@zmbh.uni-heidelberg.de
hSP-C (surfactant protein-C)	rtTA	tg	respiratory epithelium	Tichelaar et al., 2000	jeff.whitset@chmcc.org
rCcsp (Clara cell secretory protein)	rtTA	tg	respiratory epithelium	Tichelaar et al., 2000	jeff.whitset@chmcc.org
rCC10 (Clara cell 10 kDa protein)	rtTA tTS	tg	lung (Clara cells)	Ray et al., 1997 Zhu et al., 2001	jack.elias@yale.edu
bOpsin	rtTA	tg	photoreceptors	Chang et al., 2000	dzack@bs.jhmi.edu
mIRBP (interphotoreceptor retinoid-binding protein)	rtTA	tg	photoreceptors	Chang et al., 2000	dzack@bs.jhmi.edu
αCaMKII	tTA rtTA	tg	brain (neurons of neocortex, hippocampus, amygdala, basal ganglia)	Mayford et al., 1996 Mansuy et al., 1998	erk5@columbia.edu
NSE (neuron specific enolase)	tTA	tg	striatum, cerebellum, CA1-region of hippocampus, neocortex (deep layers)	Chen et al., 1998	eric.nestler@qm.yale.edu
rGH (growth hormone)	rtTA	tg	pituitary gland (somatotropes)	Roh et al., 2001	kudlow@uab.edu
rPRL (prolactin)	tTA	tg	pituitary gland (lactotropes)	Roh et al., 2001	kudlow@uab.edu
PrP (prion protein)	tTA	tg	brain (neocortex, entorhinal cortex, hippocampus, subst. nigra, thalamus, cerebellum)	Tremblay et al., 1998	stanley@ind.ucsf.edu
rNestin (tog. with IRES-β-geo)	rtTA	tg	neuroepithelium (tel-, mes-, rhombencephalon, spinal cord, retina, trigeminal ganglion)	Mitsuhashi et al., 2001	reeves@helix.mgh.harvard.edu
hRB (retinoblastoma) (tog. with tetO-CRE)	rtTA	tg	retinal ganglion layer neurons, cerebellar Purkinje cells, thalamus, myocytes of thigh muscles	Utomo et al., 1999	leew@uthscsa.edu
hPmp22 (peripheral myelin protein 22)	tTA	tg (YAC)	Schwann cells	Perea et al., 2001	c.huxley@ic.ac.uk
mip2 (proinsulin gene II promoter) (tog. with tetO-PDX-1as)	rtTA	tg	pancreatic β-cells	Lottmann et al., 2001	rwalther@mail.uni-greifswald.de
rip (rat insuline II promoter)	rtTA	tg	pancreatic β-cells	Thomas et al., 2001	jhabener@partners.org
mAlb (albumin)	tTA	tg	liver	Manickan et al., 2001	JakeL@bdg10.niddk.nih.gov
mMup (major urinary protein)	tTA	tg	liver	Manickan et al., 2001	JakeL@bdg10.niddk.nih.gov
rLAP (liver enriched activator protein)	tTA	tg	liver	Kistner et al., 1996	h.bujard@zmbh.uni-heidelberg.de
bk5 (keratin 5)	tTA rtTA	tg	skin (epidermal basement layer and hair follicles)	Diamond et al., 2000	glicka@dc37a.nci.nih.gov
bK6 (keratin 6)	tTA	tg	skin	Guo et al., 1999	obrient@alhs.org
hK14 (keratin 14)	rtTA	tg	cornified and non-cornified squamous epithelia (skin, esophagus, tongue, cornea)	Xie et al., 1999	kudlow@endo.dom.uab.edu
hK18 (keratin 18)	rtTA	tg	trachea, bronchi, lungs, submucosal glands	Ye et al., 2001	jhu@sickkids.on.ca
mTyr (tyrosinase)	rtTA	tg	melanocytes	Chin et al., 1999	ron_depinho@dfci.harvard.edu lynda_chin@dfci.harvard.edu
mEdnrb (endothelin receptor B)	tTA rtTA	ki	melanocytes, enteric neurons	Shin et al., 1999	smt@princeton.edu
Fabpl^4xat-132 (fatty acid binding protein)	rtTA	tg	small intestine, cecum, colon, bladder	Saam and Gordon, 1999	jgordon@molecool.wustl.edu
rWap (whey acidic protein) (tog. with tetO-CRE)	rtTA	tg	mammary epithelial cells, (kidney glomeruli)	Utomo et al., 1999	leew@uthscsa.edu
MMTV-LTR	tTA	tg	mammary gland, salivary gland, seminal vesicle, Leydig cells, bone marrow (brain, kidney, liver, spleen)	Hennighausen et al., 1995	paf@georgetown.edu lotharh@nih.gov
MMTV-LTR	rtTA	tg	mammary gland, salivary gland, seminal vesicle	D’Cruz et al., 2001 Gunther et al., 2002	chodosh@mail.med.upenn.edu
β-lactoglobulin (tog. with tetO-αlactalbumin)	rtTA	tg	mammary gland	Soulier et al., 1999	vilotte@biotec.jouy.inra.fr
hMCK (muscle creatine kinase)	tTA	tg	striated muscle	Ghersa et al., 1998	rob.hooft@serono.com
MCK (muscle creatine kinase)	tTA	tg	striated muscle	Ahmad et al., 2000	amalf001@mc.duke.edu
rαMHC (alpha myosin heavy chain)	tTA rtTA	tg	cardiac myocytes	Yu et al., 1996 Passman and Fishman, 1994 Valencik and McDonald, 2001	fishman@aecom.yu.edu mcdonald.john@mayo.edu
SM22α	tTA	tg	vascular smooth muscle cells	Ju et al., 2001	mr@sickkids.on.ca
mTek	tTA	tg	endothel (embryonic)	Sarao et al., 1998	ddumont@sunnybrook.on.ca
mTie	tTA	tg	endothel (adult)	Sarao et al., 1998	ddumont@sunnybrook.on.ca
Ig heavy chain-enhancer/SRα-promoter	tTA	tg	hematopoietic cells	Felsher et al., 1999	felsher@itsa.ucsf.edu
Ig heavy chain-enhancer/minimal promoter	tTA	tg	developing B- and T-cells in spleen and thymus (lymphopoiesis); skeletal muscle	Hess et al., 2001	thomas.wirth@medizin.uni-ulm.de
hCD2	rtTA	tg	T-cells	Legname et al., 2000	rzamoys@nimr.mrc.ac.uk
Lck	tTA	tg	T-cells	Leenders et al., 2000	cbdm@joslin.harvard.edu
MHCIIEα^κ	tTA	tg	thymic epithelial cells	Witherden et al., 2000	cbdm@igbmc.u-strasbg.fr
murine SM22 promoter	rtTA	tg	smooth muscle	West et al. 2004	david.rodman@uchsc.edu
Foxg1 genomic locus	tTA	ki	brain (progenitors)	Hanashima et al. 2004	fishell@saturn.med.nyu.edu
humanCD34 YAC	tTA	tg	haematopoietic stem cells,CMPs and MEPs, megakaryocytes	Huettner et al., 2003	dtenen@bidmc.harvard.edu
surfactant protein C promoter	rtTA	tg	lung	Mucenski et al. 2003	michael.mucenski@cchmc.org
Clara cell secretoryprotein promoter	rtTA	tg	lung	Mucenski et al. 2003	michael.mucenski@cchmc.org
tyrosinase promoter and Locus Control Region (LCR)	rtTA	tg	retina	Lavado et al. 2003
liver activator protein (LAP) promoter	rtTA	tg	kidney and liver	Gallagher et al. 2003	ralph.witzgall@vkl.uni-regensburg.de
human podocin (NPHS2) gene promoter	rtTA	tg	podocytes in the kidney	Shigehara et al., 2003	jbkopp@nih.gov
GABA(A) receptor alpha6 gene promoter	rtTA	tg	cerebellar granule cells of the brain	Yamamoto et al., 2003	Yamamoto.Mutsuya@mf.m-pharma.co.jp
small-conductance Ca2^+ activated K^+ channel	tTA	ki	mesenteric arteries of the endothelium	Taylor et al., 2003	mtnelson@zoo.uvm.edu
Tet- promoter	tTA	tg	various tissues	Hwang et al., 2001	kimyongkyu@hanmail.net.
rat Clara cell secretory protein 2.3-kb promoter	rtTA	tg	lung	Yan et al., 2003	Cong.Yan@cchmc.org
human b-actin promoter	tTA	tg	various tissues	Lamposa et al., 2003	pg.wells@utoronto.ca
mouse muscle creatine kinase (MCK) promoter	rtTA	tg	skeletal muscle	Grill et al., 2003	pba@email.arizona.edu
majorimmediate-early human CMV promoter and enhancer	tTA	tg	multiple tissues	Haribhai et al., 2003	cwilliam@mcw.edu
hCMVenhancer/chicken -actin promoter	rtTA	tg	multiple tissues but not in haemopoietic organs	Manfra et al., 2003	sergio.lira@mssm.edu
mouse alpha-myosin heavy chain promoter	tTA/rtTA	tg	heart	Sanbe et al., 2003	jeff.robbins@chmcc.org
MMTV-LTR	rtTA	tg	mammary gland	Gunther et al., 2003	chodosh@mail.med.upenn.edu
SM22promoter	tTA	tg	vascular SMCs of aorta, carotid, mesentery, liver,lung, kidney, and spleen	You et al., 2003	mansoor.husain@utoronto.ca
murine rhodopsin promoter	tTA	tg	photoreceptor cells of the outer nuclear layerof the retina	Angeletti et al., 2003	marigo@tigem.it
rat insulin promoter	tTA	tg	beta-cells of the pancreas	Christen et al., 2002	matthias@liai.org
small-conductance Ca^2+-activated potassium channel (SK channel)	tTA	tg	magnocellular neurons of the supraoptic nucleus and in many smooth muscles, including theuterus	Bond et al., 2000	adelman@ohsu.edu
Clara cell–specific CC10 promoter	rtTA	tg	lung, airways	Mehrad et al., 2002	borna.mehrad@utsouthwestern.edu
human SP-C promoter	rtTa	tg	peripheral respiratory epithelial cells in the lungs of fetal[postconception (pc) day 15] and adult mice	Clark et al., 2001 Pearl et al., 2002	jeff.whitsett@chmcc.org
ratCCSP promoter	rtTA	tg	tracheobronchial and type II cells	Clark et al., 2001 Pearl et al., 2002	jeff.whitsett@chmcc.org
tek/Tie2 promoter/intron enhancer	rtTA	tg	endothelial cells	Teng et al., 2002	jamie.topper@mpi.com
Pdx1 gene	tTA	ki	pancreas	Holland et al., 2002	raymond.macdonald@utsouthwestern.edu
immunoglobulin heavy chain enhancer and the SRa promoter (EmSR)	tTA	tg	haematopoietic cells and immature osteoblasts	Jain et al., 2002 Felscher et al., 1999	dfelsher@leland.stanford.edu
neuron-specific enolase (NSE) promoter	tTA	tg	brain	Sakai et al., 2002	ronald.duman@yale.edu
CMV enhancer/chicken-actin promoter	rtTA	tg	high levels of  expressionin heart; moderate expression levels in skin, kidney, thymus,and lung; and low expression levels in spleen and liver	Wiekowski et al., 2001	maria.wiekowski@spcorp.com
human K14 promoter	tTA	tg	mammary gland	Dunbar et al., 2001	john.wysolmerski@yale.edu
mouse albuminpromoter/enhancer	tTa	tg	skeletal muscle, heart, liver, lung and spleen	Raben et al., 2001	rabenn@arb.niams.nih.gov
Lck proximal promoter	tTA	tg	lymphoid organs (with the exception of a weak signal in the ovaries)	Labrecque et al., 2001	cb@joslin.harvard.edu
mouse proinsulin gene II promoter	rtTA	tg	-cells of pancreatic islets.	Lottmann et al., 2002	rwalther@mail.uni-greifswald.de
hCMV	tTA/rtTA	tg in ES cells	multiple tissues	Fedorov et al., 2001	rappur@mail.uni-wuerzburg.de
prion protein (PrP) promoter	tTA	tg	neuronal and glial cells	Gotz et al., 2001	goetz@bli.unizh.ch
surfactant protein C promoter	rtTA	tg	lung epithelial cells	Perl et al. 2002 Nguyet et al. 2004	nnguyen@imwustl.edu
SM22a promoter	rtTA	tg	arterial smooth muscle and brown fat tissue	Bernal-Mizrachi et al. 2005	csemenko@im.wustl.edu
keratin 12 gene locus	rtTA	ki	corneal epithelium	Chikama et al. 2005	Winston.Kao@uc.edu
liver-specific human apoE promoter	rtTA	tg	liver	Xu et al. 2005	xiguchen@163.com
platelet factor 4 promoter	rtTA	tg	megakaryocytes and platelets	Nguyen et al. 2005	ravid@biochem.bumc.bu.edu
Vav promoter	tTA	tg	haematopoietic, mast cells	Wiesner et al. 2005	larga002@umn.edu
nestin promoter (5-kb nestin promoter and the 700-bp second intron of the nestin gene)	rtTA-M2-GFP	tg	subventricular zone and the dentate gyrus	Yu et al. 2005	Steven.Kernie@utsouthwestern.edu
murine keratocan promoter	rtTA	tg	cornea stromal keratocytes	Hayash et al. 2005	Winston.Kao@uc.edu
bovinekeratin 5 (K5) promoter	NLS-rtTA	tg	basal layer of stratifiedepithelium including the epithelial stem cells	Vitale-Cross et al. 2004	sg39v@nih.gov
mouse major urinary protein promoter	tTA	tg	liver	Manickan et al. 2001 Lindeberg et al. 2005	JakeL@bdg10.niddk.nih.gov
Glial fibrillary acidic protein (GFAP)	tTA	tg	astrocytes	Wang et al. 2004	icamp@mmb.usyd.edu.au
SOX 10  gene locus	rtTA	ki	emerging neural crest, several of its derivatives and oligodendrocytes	Ludwig et al. 2004	m.wegner@biochem.uni-erlangen.de
human VMD2 promoter	rtTA	tg	retinal pigmented epithelial cells	Oshima et al. 2004	pcampo@jhmi.edu
human Involucrin promoter	tTA/rtTA	tg	epidermis	Jaubert et al. 2004	jsegre@nhgri.nih.gov
nestin promoter and enhancer	tTA	tg	subventricular zone and rostral migratory stream, periglomerular neurons in the brain	Beech et al. 2004	robert.beech@yale.edu
CMV enhancer/chicken beta-globin promoter	rtTA	tg	most tissues	Wiekowski et al. 2001	maria.wiekowski@spcorp.com
Stem cell leukaemia gene locus	tTA-2S	ki	lineage negative, c-kit espression haematopietic stem cells, erythrocytes, megakaryocytes, granulocytes	Bockamp et al. 2006	bockamp@mail.uni-mainz.de
Albumin / MUP (mouse urinary protein   promoter)	tTA	tg	liver	Manickan et al. 2001	JakeL@bdg10.niddk.nih.gov
Growth hormone (GH) PRL-promoter	tTA/rtTA	tg	pituitary glandl, lactotrope-specific expression	Roth et al. 2001	kudlow@uab.edu
12.4 kb murine Villin promoter	tTA-2S	tg	intestinal epithelium	Roth et al. 2008	m.j.m.smits@erasmusmc.nl
Vav promoter	tTA	tg	hematopoietic cells	Kim et al. 2007	llarga002@umn.edu

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last edited by Kira Becker on 29.08.2008